Tetrahedron Asymmetry p. 2229 - 2232 (1998)
Update date:2022-07-30
Topics:
Conde, Santiago
Fierros, Marta
Rodriguez-Franco, Maria Isabel
Puig, Carles
Resolution of 1-(4-amino-3-chloro-5-cyanophenyl)-2-bromo-1-ethanol has been achieved by ethanol enantioselective lipase-catalysed alcoholysis, hydrolysis and acylation. Although a good enantioselectivity was observed in the three reactions, the best results were obtained by hydrolysis. This α- bromohydrin is an intermediate in the synthesis of a new adrenergic agent.
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