
Tetrahedron Letters p. 6181 - 6184 (1998)
Update date:2022-07-30
Topics:
Guy, Alexandre
Durand, Thierry
Roland, Arlene
Cormenier, Emmanuelle
Rossi, Jean-Claude
The first total synthesis of ent-15(RS)-2,3-dinor-5,6-dihydro-8-epi- PGF2α 1 is described using diacetone-D-glucose as starting material. The major urinary metabolite of the isoprostane 8-epi-PGF2α is 2,3-dinor-5,6- dihydro-8-epi-PGF2α, which is a potent lipid peroxidation index to obtain an integrated assessment of oxidative stress in humans.
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