Bulletin of the Chemical Society of Japan p. 423 - 428 (2000)
Update date:2022-08-04
Topics:
Hasegawa, Tomoyuki
Yamamoto, Hisashi
(R)-2-Propyloctanoic acid has been developed as a novel therapeutic agent for Alzheimer's disease. A large-scale synthesis of this candidate was achieved by using Oppolzer's camphorsultam as a chiral auxiliary under improved conditions. It was essential for the successful synthesis of this compound to utilize a new removal method for the chiral source with a combination of tetrabutylammonium hydroxide and hydrogen peroxide. The present process afforded the desired product in high yield with high optical purity.
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