Tetrahedron Letters p. 6139 - 6142 (1998)
Update date:2022-09-26
Topics:
Py, Sandrine
Harwig, Curtis W.
Banerjee, Srabani
Brown, David L.
Fallis, Alex G.
The synthesis of the bicyclic enediyne compounds 14-18 is described. The bicyclo[7.3.1]trideca-4,9-dien-2,6-diynes (21) are calicheamicin-taxoid mimics, that possess the Taxotere side chain and an enediyne core. Cyclization of the iodo-aldehyde 13 [CrCl2(THF)2] afforded the bicyclic alcohol 14 as a single diastereomer (76%) and allylic oxidation (SeO2) followed by reaction with the oxazolidine intermediate 19, resolution and hydrolysis provided the taxamycins 21.
View MoreContact:021
Address:Pudong
Kunshan Yalong Trading Co,.Ltd
Contact:86-512-57621185
Address:805-807 Room Hongqiao Mansion ,1088 West Qianjin Road, Kunshan, Jiangsu，China
Contact:13736652831
Address:NO.273 SHANGHAI SOUTH STREET,LUQIAO DISTRICT,ZHEJIANG PROVINCE,CHINA.
Contact:--
Address:80G, No.1 Building, Guodu Development Mansion, No. 182 Zhaohui Road, Hangzhou City, Zhejiang Province,China.
Contact:+86-512-69561895
Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Doi:10.1002/anie.200604810
(2007)Doi:10.1002/hlca.19680510831
(1968)Doi:10.1016/S0040-4039(98)01589-5
(1998)Doi:10.1016/S0008-6215(98)00013-5
(1998)Doi:10.1023/A:1022563529344
(2002)Doi:10.1007/BF00478067
()
