Tetrahedron Letters p. 6139 - 6142 (1998)
Update date:2022-09-26
Topics:
Py, Sandrine
Harwig, Curtis W.
Banerjee, Srabani
Brown, David L.
Fallis, Alex G.
The synthesis of the bicyclic enediyne compounds 14-18 is described. The bicyclo[7.3.1]trideca-4,9-dien-2,6-diynes (21) are calicheamicin-taxoid mimics, that possess the Taxotere side chain and an enediyne core. Cyclization of the iodo-aldehyde 13 [CrCl2(THF)2] afforded the bicyclic alcohol 14 as a single diastereomer (76%) and allylic oxidation (SeO2) followed by reaction with the oxazolidine intermediate 19, resolution and hydrolysis provided the taxamycins 21.
View MoreHangzhou Dingyan Chem Co., Ltd
website:http://www.dingyanchem.com
Contact:86-571-87157530
Address:RM.1118,NO.1 Building, Baiyun Tower,Jianggan Area, Hangzhou city, China,310004
Hangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Hangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Heading（Nanjing）Pharmtechnologies
Contact:86 25 58467899-950 025-58862846-950
Address:Room C413 Fengyu Building, 115 Fucheng Road, Haidian District, Beijing 100142, China
Landz International Company Ltd.
Contact:0086-21-58891610
Address:985 Dongfang Road, Pudong, Shanghai 200122 China
Doi:10.1002/anie.200604810
(2007)Doi:10.1002/hlca.19680510831
(1968)Doi:10.1016/S0040-4039(98)01589-5
(1998)Doi:10.1016/S0008-6215(98)00013-5
(1998)Doi:10.1023/A:1022563529344
(2002)Doi:10.1007/BF00478067
()
