Bioorganic and Medicinal Chemistry Letters p. 327 - 332 (1999)
Update date:2022-09-26
Topics:
Heitsch, Holger
Wagner, Adalbert
Schoelkens, Bernward A.
Wirth, Klaus
The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations.
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