Definition of the effect and role of the bleomycin A2 valerate substituents: Preorganization of a rigid, compact conformation implicated in sequence-selective DNA cleavage

DOI: 10.1021/ja9816640

Source and publish data:

Journal of the American Chemical Society p. 9149 - 9158 (1998)

Update date:2022-08-04

Topics:

Authors:

Boger, Dale L.

Ramsey, Timothy M.

Cai, Hui

Hoehn, Silvia T.

Stubbe, JoAnne

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Article abstract of DOI:10.1021/ja9816640

The synthesis and a comparative study of deglycobleomycin A₂ analogues containing key modifications in the valerate subunit are described in efforts that define the role of the linker length and its substituents. In addition to demonstrating th

Full text of DOI:10.1021/ja9816640

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