Synthesis of methyl derivatives of linear and angular thienocoumarins and thiopyranocoumarins

Article abstract of DOI:10.1002/jhet.5570350411

New linear and angular thienocoumarins and thiopyranocoumarins were synthesized. The key intermediates were appropriate methyl derivatives of 7- mercaptocoumarin, which were considered with chloroketones or propargyl chloride. Thioethers were cyclized under various conditions in order to determine which methods produced the best yields of the desired thienocoumarins 15, 16, 17, 18, 22, 23, 24, 27 and thiopyranocoumarins 28 and 29.