The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives

DOI: 10.1016/S0960-894X(99)00539-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3137 - 3142 (1999)

Update date:2022-08-05

Topics:

Authors:

Smith, David G.

Gribble, Andrew D.

Haigh, David

Ife, Robert J.

Lavery, Patrick

Skett, Peter

Slingsby, Brian P.

Stacey, Rachel

Ward, Robert W.

West, Andrew

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Article abstract of DOI:10.1016/S0960-894X(99)00539-9

Aryl hydroxylamine derivatives have been synthesised that are some of the most potent inhibitors of hCMV protease prepared to date (IC₅₀ 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by a

Full text of DOI:10.1016/S0960-894X(99)00539-9

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