The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives

DOI: 10.1016/S0960-894X(99)00539-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3137 - 3142 (1999)

Update date:2022-08-05

Topics:

Authors:

Smith, David G.

Gribble, Andrew D.

Haigh, David

Ife, Robert J.

Lavery, Patrick

Skett, Peter

Slingsby, Brian P.

Stacey, Rachel

Ward, Robert W.

West, Andrew

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00539-9

Aryl hydroxylamine derivatives have been synthesised that are some of the most potent inhibitors of hCMV protease prepared to date (IC₅₀ 14-60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by a

Full text of DOI:10.1016/S0960-894X(99)00539-9

Products guided by the article

Product name:2-[4-(3-hydroxyamino-benzoyl)-benzyl]-5-methyl-thieno[2,3-d][1,3]oxazin-4-one

Cas No:214553-56-7

R&D Labs maybe for 214553-56-7

Zhangjiagang Golden Reach Fine Chemical Co.,LTD.

Contact:+86-512-6585 6968

Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China
Shandong Wanda Organosilicon New Material Co., Ltd

Contact:+86-21-54177116;54302881

Address:R1318 Greenland No. 3 Lane 58 Xinjian East Rd., Minhang
Liao Cheng All Win Chemicals Co.,LTD

Contact:86+0635-2991582

Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China
Zhengzhou Minzhong Pharmaceutical Co.,ltd

Contact:0086-371-65797115

Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Tianjin Realet Chemical Technology Co.,Ltd.

website:http://www.realetchem.com

Contact:+86-022-58788819

Address:shuanggang industrial park

Relevant to this article

Ethene polymerization behavior of MAO-Activated dichloridotitanium complexes bearing Bi- and tetradentate salicylaldimine derivatives

Doi:10.1002/ejic.200900840
(2010)
Facile syntheses of TiCl₂(TADDOLate)(L₂), efficient asymmetric ethylation of PhCHO, and an unexpected rearrangement of the tetramethyl analogue of the TADDOL ligand

Doi:10.1021/om980570w
(1998)
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.

Doi:10.1021/jm980290i
(1998)
The preparation, crystal structure and some reaction chemistry of Bromo (η⁵-penta- phenylcyclopentadienyl) dicarbonylosmium (II) , [Os (η⁵-C⁵Ph⁵) (CO) ²Br]

Doi:10.1016/S0277-5387(97)00448-8
(1998)
Stereoselective synthesis of γ-aminoallyltins from vinyltin acetals

Doi:10.1016/S0022-328X(98)00663-9
(1998)
Reactions with hydrazonoyl halides XVII^[1]: Synthesis and reactions of 1-bromo-2-[4-(N-piperidinosulfonyl)phenyl]ethanedione-1-arylhydrazone

Doi:10.1080/10426509708031594
(1997)

Article Doi