Tetrahedron Letters p. 7177 - 7180 (1998)
Update date:2022-08-03
Topics:
Barboni, Luciano
Lambertucci, Catia
Ballini, Roberto
Appendino, Giovanni
Bombardelli, Ezio
A conformationally constrained analogue of the paclitaxel side-chain was synthesised in an enantioselective way from ethyl 1H-indene-2-carboxylate. Coupling with 7-triethylsilylbaccatin III and deprotection afforded 2',2''- methylenepaclitaxel, a novel analogue of the natural product retaining anticancer activity.
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Doi:10.1007/BF00757634
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