Tetrahedron Letters p. 8377 - 8380 (1998)
Update date:2022-09-26
Topics:
Clayden, Jonathan
Pink, Jennifer H.
Westlund, Neil
Wilson, Francis X.
By substituting deuterium for hydrogen at positions of high kinetic acidity in amides and carbamates, the usual regiochemical course of their reactions with alkyllithiums (ortholithiation vs. lateral lithiation vs. nucleophilic addition) can be altered or overturned by the kinetic isotope effect. The deuterium substituent functions in these reactions as a protecting group for carbon.
View Morewebsite:http://www.win-winchemical.com
Contact:0086-577-64498589
Address:6F, No. 396 Xingping Road, Longwan Industrial Zone, Wenzhou City, Zhejiang, 325000 P.R.China
Contact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-5161 3915
Address:Shanghai YangPu
Shanghai doly chemical Co.,Ltd
Contact:+86-21-34716221
Address:No.328,WuHe Roard,MinHang,ShangHai China
Tianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Doi:10.1016/j.jcat.2020.09.032
(2020)Doi:10.1016/S0040-4039(01)97679-8
(1969)Doi:10.3390/ph14070650
(2021)Doi:10.1016/j.polymer.2016.08.007
(2016)Doi:10.1080/07328319908045598
(1999)Doi:10.1515/znb-1999-0109
(1999)
