H-phosphonate derivatives as novel peptide deformylase inhibitors

DOI: 10.1016/S0960-894X(98)00443-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2479 - 2482 (1998)

Update date:2022-08-04

Topics:

Authors:

Hu, Yun-Jin

Rajagopalan, P. T. Ravi

Pei, Dehua

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Article abstract of DOI:10.1016/S0960-894X(98)00443-0

Peptide deformylase catalyzes the removal of the N-terminal formyl group from nascent polypeptides during prokaryotic protein maturation and is essential for bacterial survival. Its absence from eukaryotic organisms makes it an attractive target for desig

Full text of DOI:10.1016/S0960-894X(98)00443-0

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