Preparation and diastereoselective functionalization of a new chiral non racemic bicyclic hydrazinolactam

DOI: 10.1016/S0040-4039(98)01813-9

Source and publish data:

Tetrahedron Letters p. 8081 - 8084 (1998)

Update date:2022-08-04

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Authors:

Roussi, Fanny

Bonin, Martine

Chiaroni, Angele

Micouin, Laurent

Riche, Claude

Husson, Henri-Philippe

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Article abstract of DOI:10.1016/S0040-4039(98)01813-9

Starting with R-(-)-phenylglycinol, the synthesis of a new bicyclic hydrazinolactam 3 was realized on a multigram scale. The reaction scope of the corresponding enolate with various electrophiles has been studied. Good to excellent diastereoselectivities were obtained.

Full text of DOI:10.1016/S0040-4039(98)01813-9

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