
Tetrahedron Letters p. 7755 - 7758 (1998)
Update date:2022-08-03
Topics:
Bailey, Patrick D.
Baker, S. Richard
Boa, Andrew N.
Clayson, Joanne
Rosair, Georgina M.
A range of protected α-heterosubstituted analogues of glycine were synthesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I; R = CH2Ph, (s)-CHMePh]; the final products included derivatives of glycine possessing N, O, F or S in the α-position, and the first example of a free α-fluoro-α-amino acid (α-fluorobetaine) whose structure was confirmed by X-ray crystal structure determination.
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