2-pyridinyl-3(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

DOI: 10.1016/S0960-894X(98)00499-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2777 - 2782 (1998)

Update date:2022-09-26

Topics:

Authors:

Friesen, Richard W.

Brideau, Christine

Chan, Chi Chung

Charleson, Stella

Deschenes, Denis

Dube, Daniel

Ethier, Diane

Fortin, Rejean

Gauthier, Jacques Yves

Girard, Yves

Gordon, Robert

Greig, Gillian M.

Riendeau, Denis

Savoie, Chantai

Wang, Zhaoyin

Wong, Elizabeth

Visco, Denise

Xu, Li Jing

Young, Robert N.

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Article abstract of DOI:10.1016/S0960-894X(98)00499-5

A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of cyclooxygenase, COX-1, and COX-2. Optimum COX-2 activity is observed by introduction of a substituent at C5 of the central pyridine. 5- Chloro-3-(4-methylsulfonyl)phenyl-2(2-methyl-5-pyridinyl)pyridine 33 was identified as the optimum compound in this series.

Full text of DOI:10.1016/S0960-894X(98)00499-5

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