Tetrahedron Letters p. 8557 - 8560 (1998)
Update date:2022-08-04
Topics: Stereoselective Michael addition Experimental terms Text format 5-glyco-4-nitrocyclohex-1-enes
Areces
Gil
Higes
Roman
Serrano
Michael additions of 5-glyco-4-nitrocyclohex-1-enes (2 and 3) proceeded in a stereoselective way, leading in each case to single adducts in which the electron-deficient alkenes add on the C-4 of the cyclohexene rings, in a trans mode to the adjacent, sterically demanding, sugar side-chain. When dimethyl maleate or dimethyl fumarate and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were used, there was in situ elimination of nitrous acid, and the product consisted in a 1:1 mixture of the epimeric α,β-unsaturated esters 7.
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Doi:10.1002/jhet.5570350236
(1998)Doi:10.1016/S0040-4020(98)00891-6
(1998)Doi:10.1016/S0040-4039(98)01964-9
(1998)Doi:10.1021/jo981835j
(1998)Doi:10.1080/00397910902906503
(2009)Doi:10.1002/adsc.202001051
(2021)