Spiro-substituted piperidines as neurokinin receptor antagonists. III. Synthesis of (±)-N-[2-(3,4-dichlorophenyl)-4-(spiro-substituted piperidin- 1'-yl)butyl]-N-methylbenzamides and evaluation of NK1-NK2 dual antagonistic activities

DOI: 10.1248/cpb.46.1538

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1538 - 1544 (1998)

Update date:2022-08-05

Topics:

Authors:

Kubota, Hirokazu

Kakefuda, Akio

Okamoto, Yoshinori

Fujii, Masahiro

Yamamoto, Osamu

Yamagiwa, Yoko

Orita, Masaya

Ikeda, Ken

Takeuchi, Makoto

Shibanuma, Tadao

Isomura, Yasuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.46.1538

To discover a novel NK₁-NK₂ dual antagonist, we have synthesized a series of spiro-substituted piperidines utilizing YM-35375 as a lead compound, and evaluated affinities for NK₁ and NK₂ receptors. In the N- met

Full text of DOI:10.1248/cpb.46.1538

NII-Electronic Library Service

Products guided by the article

Product name:(+/-)-N-<2-(3,4-dichlorophenyl)-4-methanesulfonyloxybutyl>-3,4,5-trimethoxy-N-methylbenzamide

Cas No:217467-22-6

R&D Labs maybe for 217467-22-6

Shanghai Kefu Chemical Co.,Ltd.

Contact:+86-21-34616196

Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
jiangsu senxuan pharmaceutical and chemical co.,ltd

Contact:86-523-87982810

Address:hongqiao industrial zone,taixing,jiangsu china
Nanjing Chemical Material Corp.(NCMC)

website:http://www.njchemm.com

Contact:0086-25-83172879

Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
Suzhou Zhonghelong Chemical Tech Co., Ltd【License cancellation】

Contact:+86 571-12345678

Address:Dunhuang Road, Suzhou Industrial Park, No.128 building 701 room Mansion
Weifang Dongxing Chitosan Factory

website:http://dxchitosan.lookchem.com/

Contact:13475651157

Address:Weifang city ,shandong province

Relevant to this article

Study of the Oxidative Cleavage Proposed in the Biogenesis of Transtaganolides/Basiliolides: Pyran-2-one Aromaticity-Mediated Regioselective Control and Biogenetic Implications

Doi:10.1002/ejoc.201901894
(2020)
Selective cleavage of isopropyl aryl ethers by aluminum trichloride

Doi:10.1021/jo9808526
(1998)
Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists

Doi:10.1021/jm050879z
(2006)
Enantio- And diastereoselective synthesis of b-Aryl-b-pyrazolyl a-amino acid esters via copper-catalyzed reaction of azomethine ylides with benzylidenepyrazolones

Doi:10.1002/adsc.201801137
(2019)
A spectroscopic characterization of a phenolic natural mediator in the laccase biocatalytic reaction

Doi:10.1016/j.molcatb.2013.08.013
(2013)
Biologically active acylthioureas and their Ni(II) and Cu(II) Complexes: Structural, spectroscopic, anti-proliferative, nucleolytic and antimicrobial studies

Doi:10.1016/j.ica.2021.120590
(2021)

Article Doi