Spiro-substituted piperidines as neurokinin receptor antagonists. III. Synthesis of (±)-N-[2-(3,4-dichlorophenyl)-4-(spiro-substituted piperidin- 1'-yl)butyl]-N-methylbenzamides and evaluation of NK1-NK2 dual antagonistic activities

DOI: 10.1248/cpb.46.1538

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1538 - 1544 (1998)

Update date:2022-08-05

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Authors:

Kubota, Hirokazu

Kakefuda, Akio

Okamoto, Yoshinori

Fujii, Masahiro

Yamamoto, Osamu

Yamagiwa, Yoko

Orita, Masaya

Ikeda, Ken

Takeuchi, Makoto

Shibanuma, Tadao

Isomura, Yasuo

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Article abstract of DOI:10.1248/cpb.46.1538

To discover a novel NK₁-NK₂ dual antagonist, we have synthesized a series of spiro-substituted piperidines utilizing YM-35375 as a lead compound, and evaluated affinities for NK₁ and NK₂ receptors. In the N- met

Full text of DOI:10.1248/cpb.46.1538

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