Synthesis of a monocyclic core of the antifungal sordarins

Article abstract of DOI:10.1016/S0040-4039(98)01910-8

An enantiospecific synthesis of a monocyclic core of the antifungal sordarins and sordaricins has been achieved. This synthesis is based on the conversion of (+)-3,9-dibromocamphor into a 1,1,2,2,5-pentasubstituted cyclopentane bearing all the key functionalities present in these antifungals.