Stereoisomers of cyclic urea HIV-1 protease inhibitors: Synthesis and binding affinities

Article abstract of DOI:10.1021/jm980255b

We have synthesized stereoisomers of cyclic urea HIV-1 protease inhibitors to study the effect of varying configurations on binding affinities. Four different synthetic approaches were used to prepare the desired cyclic urea stereoisomers. The original cy