Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models

DOI: 10.1016/S0960-894X(98)00472-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2685 - 2688 (1998)

Update date:2022-08-05

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Authors:

Wang, Chenguang

McFadyen, Iain J.

Traynor, John R.

Mosberg, Henry I.

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Article abstract of DOI:10.1016/S0960-894X(98)00472-7

A pair of diastereomeric peptidomimetics based upon opioid receptor- binding pharmacophore models derived for a series of opioid tetrapeptide was synthesized. Both analogues display high opioid receptor affinity, moderate selectivity for the μ opioid rece

Full text of DOI:10.1016/S0960-894X(98)00472-7

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