Efficient synthesis of substituted oxopiperazines from amino acids

Article abstract of DOI:10.1016/S0040-4039(98)01878-4

The synthesis of substituted oxopiperazines, which may act as conformationally constrained peptide mimics, is reported. The synthesis is based on the cyclization of sulfonamide dipeptides with dibromoethane as the 1,2-dielectrophile. Alternatively, these