Bioorganic and Medicinal Chemistry Letters p. 2675 - 2680 (1998)
Update date:2022-08-02
Topics:
Mewshaw, Richard E.
Verwijs, Antoine
Shi, Xiaojie
McGaughey, Georgia B.
Nelson, James A.
Mazandarani, Hossein
Brennan, Julie A.
Marquis, Karen L.
Coupet, Joseph
Andree, Terrance H.
The synthesis of several bioisoteric analogs based on the 3-OH-N1- phenylpiperazine dopamine D2 agonist template (i.e., 4) is described. The indolone (5) and 2-CF3-benzimidazole (13) were observed to have excellent affinity for the D2 receptor. Several D4 selective compounds were also identified. Molecular modeling studies and a putative bioactive conformation are discussed.
View MoreJiYi Chemical (Beijing) Co., Ltd.
Contact:+86-10-89385733
Address:Shilou Town of Fangshan District， Beijing
Weifang Adde Economic And Trade Co.,LTD.
Contact:86-536-8885548
Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Chengdu Pukang Biotechnology Co., Ltd
Contact:+86-28-82550498
Address:No. 558 Rulin Road,Xinjin county,Chengdu city, China
Zhejiang Chemicals Import & Export Corporation
Contact:86-571-87043088
Address:No.37,Qingchun Road,Hangzhou,China
Zhuhai Rundu Pharmaceutical co.,Ltd
Contact:+86-756-7630755
Address:No.6,North Airport Road,Sanzao Town,Jinwan District
Doi:10.1021/om9807607
(1998)Doi:10.1016/j.ica.2015.09.022
(2015)Doi:10.1016/S0040-4039(98)02164-9
(1998)Doi:10.1039/c1jm12805a
(2011)Doi:10.1016/S0040-4039(98)02228-X
(1998)Doi:10.1016/S0968-0896(98)00164-3
(1998)
