Bioorganic and Medicinal Chemistry Letters p. 2675 - 2680 (1998)
Update date:2022-08-02
Topics:
Mewshaw, Richard E.
Verwijs, Antoine
Shi, Xiaojie
McGaughey, Georgia B.
Nelson, James A.
Mazandarani, Hossein
Brennan, Julie A.
Marquis, Karen L.
Coupet, Joseph
Andree, Terrance H.
The synthesis of several bioisoteric analogs based on the 3-OH-N1- phenylpiperazine dopamine D2 agonist template (i.e., 4) is described. The indolone (5) and 2-CF3-benzimidazole (13) were observed to have excellent affinity for the D2 receptor. Several D4 selective compounds were also identified. Molecular modeling studies and a putative bioactive conformation are discussed.
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Doi:10.1021/om9807607
(1998)Doi:10.1016/j.ica.2015.09.022
(2015)Doi:10.1016/S0040-4039(98)02164-9
(1998)Doi:10.1039/c1jm12805a
(2011)Doi:10.1016/S0040-4039(98)02228-X
(1998)Doi:10.1016/S0968-0896(98)00164-3
(1998)
