New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phneylpiperazine dopaminergic template

DOI: 10.1016/S0960-894X(98)00474-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2675 - 2680 (1998)

Update date:2022-08-02

Topics:

Authors:

Mewshaw, Richard E.

Verwijs, Antoine

Shi, Xiaojie

McGaughey, Georgia B.

Nelson, James A.

Mazandarani, Hossein

Brennan, Julie A.

Marquis, Karen L.

Coupet, Joseph

Andree, Terrance H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00474-0

The synthesis of several bioisoteric analogs based on the 3-OH-N¹- phenylpiperazine dopamine D₂ agonist template (i.e., 4) is described. The indolone (5) and 2-CF₃-benzimidazole (13) were observed to have excellent affinity for the D₂ receptor. Several D₄ selective compounds were also identified. Molecular modeling studies and a putative bioactive conformation are discussed.

Full text of DOI:10.1016/S0960-894X(98)00474-0

Products guided by the article

Product name:4-(4-Benzyl-piperazin-1-yl)-3,5-dichloro-1H-indole

Cas No:218933-42-7

R&D Labs maybe for 218933-42-7

ShangHai Original Economy-Trade Develop Co.,Ltd.,

Contact:86-21-68552131

Address:shanghai
BAODING SINO-CHEM INDUSTRY CO.,LTD

Contact:0312-5956088

Address:NO.8 FUXING ROAD,CHINA
Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Shanghai Kefu Chemical Co.,Ltd.

Contact:+86-21-34616196

Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
Changzhou Litong Chemical Co., Ltd.

website:http://www.litonchem.com/

Contact:+86-519-86301238

Address:Laoba Rd, Hutang town Changzhou Jiangsu

Relevant to this article

Synthesis and structural characterization of novel rhodium-diacylarsenido complexes

Doi:10.1021/om9807607
(1998)
Four polynuclear complexes based on a versatile salicylamide salen-like ligand: Synthesis, structural variations and magnetic properties

Doi:10.1016/j.ica.2015.09.022
(2015)
Efficient synthesis of dehydroamino acid derivatives

Doi:10.1016/S0040-4039(98)02164-9
(1998)
Photo-induced self-cleaning functions on 2-anthraquinone carboxylic acid treated cotton fabrics

Doi:10.1039/c1jm12805a
(2011)
1,3-asymmetric induction in the intramolecular [2+2] cycloaddition of alkene-keteniminium salts. Synthesis of (+)-gibberellic acid key intermediate

Doi:10.1016/S0040-4039(98)02228-X
(1998)
Total synthesis of 25-hydroxy-16,23E-diene vitamin D₃ and 1α,25-dihydroxy-16,23E-diene vitamin D₃: Separation of genomic and nongenomic vitamin D activities

Doi:10.1016/S0968-0896(98)00164-3
(1998)

Article Doi