Bioorganic and Medicinal Chemistry Letters p. 2675 - 2680 (1998)
Update date:2022-08-02
Topics:
Mewshaw, Richard E.
Verwijs, Antoine
Shi, Xiaojie
McGaughey, Georgia B.
Nelson, James A.
Mazandarani, Hossein
Brennan, Julie A.
Marquis, Karen L.
Coupet, Joseph
Andree, Terrance H.
The synthesis of several bioisoteric analogs based on the 3-OH-N1- phenylpiperazine dopamine D2 agonist template (i.e., 4) is described. The indolone (5) and 2-CF3-benzimidazole (13) were observed to have excellent affinity for the D2 receptor. Several D4 selective compounds were also identified. Molecular modeling studies and a putative bioactive conformation are discussed.
View MoreSuzhou Time-chem Technologies Co., Ltd.
Contact:0512-63983931/68086856
Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Shanghai Sungo Technology Chemical Co., Ltd
Contact:0086-21-51385579
Address:Room2010, F/20, Tonghua Plaza, NO 345 Jinxiang Road, Jinqiao Export Processing Zone, Shanghai, 201206 P.R.CHINA
website:http://www.acrospharmatech.com
Contact:+1-3234804688
Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong
Contact:86-512-87182055
Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
Doi:10.1021/om9807607
(1998)Doi:10.1016/j.ica.2015.09.022
(2015)Doi:10.1016/S0040-4039(98)02164-9
(1998)Doi:10.1039/c1jm12805a
(2011)Doi:10.1016/S0040-4039(98)02228-X
(1998)Doi:10.1016/S0968-0896(98)00164-3
(1998)
