The synthesis and biological activity of a novel series of diazepine MMP inhibitors

DOI: 10.1016/S0960-894X(98)00473-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2657 - 2662 (1998)

Update date:2022-07-30

Topics:

Authors:

Levin, Jeremy I.

DiJoseph, John F.

Killar, Loran M.

Sung, Amy

Walter, Thomas

Sharr, Michele A.

Roth, Catherine E.

Skotnicki, Jerauld S.

Albright, J. Donald

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Article abstract of DOI:10.1016/S0960-894X(98)00473-9

A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo.

Full text of DOI:10.1016/S0960-894X(98)00473-9

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Product name:3-Hydroxycarbamoyl-4-(4-methoxy-benzenesulfonyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

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