Synthesis of substituted (D)-phenylalanine derivatives by regioselective reduction of enantiomerically pure cis-2,3-disubstituted aziridines

Article abstract of DOI:10.1016/S0040-4039(98)02095-4

Various N-(R)-(+)-(α-methylbenzyl)-(2R,3R)-distributed aziridines were prepared by intramolecular cyclization. The regioselective reduction of the ring C(3)-N bond in the presence of (Boc)₂O by catalytic hydrogenation with atmospheric pressure of hydrogen provides (D)-phenylalaninol analogues in good yields.