Synthesis of substituted (D)-phenylalanine derivatives by regioselective reduction of enantiomerically pure cis-2,3-disubstituted aziridines

DOI: 10.1016/S0040-4039(98)02095-4

Source and publish data:

Tetrahedron Letters p. 9193 - 9196 (1998)

Update date:2022-08-03

Topics:

Authors:

Chang, Jae-Won

Bae, Jae Hyun

Shin, Seong-Ho

Park, Chan Sun

Choi, Daeock

Lee, Won Koo

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Article abstract of DOI:10.1016/S0040-4039(98)02095-4

Various N-(R)-(+)-(α-methylbenzyl)-(2R,3R)-distributed aziridines were prepared by intramolecular cyclization. The regioselective reduction of the ring C(3)-N bond in the presence of (Boc)₂O by catalytic hydrogenation with atmospheric pressure of hydrogen provides (D)-phenylalaninol analogues in good yields.

Full text of DOI:10.1016/S0040-4039(98)02095-4

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Product name:Acetic acid (2R,3R)-3-phenyl-1-((R)-1-phenyl-ethyl)-aziridin-2-ylmethyl ester

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