Nickel powder promoted 5-endo radical cyclisations. A concise approach to erythrina alkaloids

DOI: 10.1016/S0040-4039(98)02036-X

Source and publish data:

Tetrahedron Letters p. 8995 - 8998 (1998)

Update date:2022-08-03

Topics:

Authors:

Cassayre, Jerome

Quiclet-Sire, Beatrice

Saunier, Jean-Baptiste

Zard, Samir Z.

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Article abstract of DOI:10.1016/S0040-4039(98)02036-X

N-Alkenyl trichloroacetamides 3 undergo, upon refluxing with nickel powder and acetic acid in 2-propanol, exclusive 5-endo-trig cyclisation to afford functionalised lactams 4; these are attractive precursors of erythrina alkaloids, as demonstrated by the expedient synthesis of 3- demethoxyerythratidinone 5.

Full text of DOI:10.1016/S0040-4039(98)02036-X

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