Synthesis and pharmacological evaluation of pyrazolo[4,3-c]quinolinones as high affinity GABAA-R ligands and potential anxiolytics

DOI: 10.1016/j.bmc.2018.06.021

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3967 - 3974 (2018)

Update date:2022-08-04

Topics:

Authors:

López Rivilli, Marisa J.

Turina, Anahí V.

Bignante, Elena A.

Molina, Victor H.

Perillo, María A.

Bri?on, Margarita C.

Moyano, Elizabeth L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmc.2018.06.021

The synthesis, in vitro ligand binding study and in vivo Elevated Plus Maze test (EPM) of a series of pyrazolo[4,3-c]quinolin-3-ones (PQs) are reported. Multistep synthesis of PQs started from anilines and diethyl 2-(ethoxymethylene)malonate to give the q

Full text of DOI:10.1016/j.bmc.2018.06.021

Products guided by the article

Product name:8-bromo-2-(4-methoxyphenyl)-2H-pyrazolo[4,3-c]quinolin-3(5H)-one

Cas No:220511-11-5

R&D Labs maybe for 220511-11-5

ShangHai Ruiyi Medical Technology Co.,Ltd.

Contact:+86-21-54718086

Address:No951 Jianchuan RD，Minhang District
Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.
CGeneTech (Suzhou, China) Co., Ltd.

Contact:+86-512-62956962

Address:Room 101，Bld C11,218 Xinghu Rd.,Suzhou industrial Park
Chongqing KonAo Health Co.,Ltd

Contact:13687578375

Address:wuhan hubei china
Evergreen Chemical Industry Ltd.

Contact:86-553-4918210

Address:6#2-602 Wanhaobailing

Relevant to this article

A novel convergent method for the synthesis of α-acyl-γ- hydroxylactams and its application in the total synthesis of PI-090 and 091

Doi:10.1016/j.bmcl.2012.05.065
(2012)
Structure-affinity relationships of berbines or 5,6,13,13a-tetrahydro-8H-dibenzoquinolizines at α-adrenoceptors

Doi:10.1016/0223-5234(91)90195-S
(1991)
Synthesis of methyl esters of (2S or 2R) 2-(4-nitro-1-imidazolyl) alkanecarboxylic acids

Doi:10.1016/S0957-4166(00)86130-3
(1991)
Synthesis, antimicrobial and antioxidant activities of 2-[1-{3,5-diaryl-4, 5-dihydro-1H-pyrazolenyl}]-4-(4-nitrophenyl)-[1,3]-thiazoles

Doi:10.1007/s00044-012-0154-3
(2013)
Nickel-catalyzed dehydrogenative cross-coupling: Direct transformation of aldehydes into esters and amides

Doi:10.1002/anie.201410322
(2015)
A Concise and Enantioselective Approach to Cyclobutanones by Tandem Asymmetric Epoxidation and Enantiospecific Ring Expansion of Cyclopropylidene Alcohols. An Enantiocontrolled Synthesis of (+)- and (-)-α-Cuparenones

Doi:10.1021/jo00032a021
(1992)

Article Doi