Synthesis and biological evaluation of 14-alkoxymorphinans. 16.1 14-0-alkyl derivatives of the μ opioid receptor antagonist cyprodime

DOI: 10.3987/COM-98-S60

Source and publish data:

Heterocycles p. 489 - 497 (1998)

Update date:2022-08-03

Topics:

Authors:

Schmidhammer, Helmut

Krassnig, Roland

Greiner, Elisabeth

Traynor, John R.

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Article abstract of DOI:10.3987/COM-98-S60

The 14-O-benzyl derivatives of cyprodime and 3-hydroxycyprodime (compounds (5) and (6), respectively) were synthesized in several steps from 3-desoxynaltrexone (2a) and naltrexone (2), respectively. In the mouse vas deferens preparation it was found that

Full text of DOI:10.3987/COM-98-S60

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