Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship

DOI: 10.1016/S0040-4020(98)00406-2

Source and publish data:

Tetrahedron p. 7735 - 7748 (1998)

Update date:2022-07-31

Topics: Neurite Outgrowth Structure-Activity Relationship Experimental Chemical terms Study

Authors:

Girlanda-Junges, Celine

Keyling-Bilger, Florence

Schmitt, Gaby

Luu, Bang

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Article abstract of DOI:10.1016/S0040-4020(98)00406-2

Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω-alkanol side chain were synthesized using 'Umpolung' reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω-hydroxy side chain is a crucial factor for biological activity.

Full text of DOI:10.1016/S0040-4020(98)00406-2

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