Tetrahedron p. 7735 - 7748 (1998)
Update date:2022-07-31
Topics: Neurite Outgrowth Structure-Activity Relationship Experimental Chemical terms Study
Girlanda-Junges, Celine
Keyling-Bilger, Florence
Schmitt, Gaby
Luu, Bang
Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω-alkanol side chain were synthesized using 'Umpolung' reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω-hydroxy side chain is a crucial factor for biological activity.
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