A new and mild synthesis of β-amino acids from masked β-enamino acid derivatives

Article abstract of DOI:10.1016/S0040-4039(98)02469-1

A new method of synthesis of racemic β-amino acids 6 by reduction of masked N-substituted and N-unsubstituted β-enamino acid derivatives 4 via C- protected β-amino acids 5 is described. The process occurs with high yields, total chemoselectivity and moderate diastereoselectivity. Readily available starting materials, inexpensive reagents and mild conditions are used to furnish derivatives 5 and 6.