Isothiazoles. Part IX. An efficient synthetic route to 5-substituted-3- amino-4-arylisothiazole 1,1-dioxides and their 4,5-dihydro derivatives

Article abstract of DOI:10.1016/S0040-4020(98)01214-9

A simple method to introduce an heteroatom substituent at C-5 of isothiazole dioxides is reported. Through Michael addition reactin 5- substituted isothiazole and 4,5-dihydroisothiazole 1,1-dioxides were obtained allowing the preparation of a series of derivatives of special interst for biological studies.