Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity

DOI: 10.1248/cpb.47.246

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Chemical and Pharmaceutical Bulletin p. 246 - 256 (1999)

Update date:2022-08-03

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Authors:

Mizuno, Akira

Inomata, Norio

Miya, Mikiko

Kamei, Tomoe

Shibata, Makoto

Tatsuoka, Toshio

Yoshida, Maki

Takiguchi, Chikako

Miyazaki, Tomoko

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Article abstract of DOI:10.1248/cpb.47.246

A series of 1-aminoalkyl-pyrrolo[2,3-c]azepin-8-one derivatives was synthesized and evaluated as α₁ adrenergic and serotonin 2 (5-HT₂) receptor antagonists, with the aim of finding a novel antihypertensive agent potently exhibiting b

Full text of DOI:10.1248/cpb.47.246

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