Synthesis of imifuramine and its stereoisomers exhibiting histamine H3- agonistic activity

DOI: 10.1016/S0040-4039(99)00202-6

Source and publish data:

Tetrahedron Letters p. 2561 - 2564 (1999)

Update date:2022-08-05

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Authors:

Harusawa, Shinya

Imazu, Tomonari

Takashima, Seiichiroh

Araki, Lisa

Ohishi, Hirofumi

Kurihara, Takushi

Yamamoto, Yumiko

Atsushi Yamatodani

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Article abstract of DOI:10.1016/S0040-4039(99)00202-6

The four possible stereoisomers of a novel imidazole C-nucleoside derivative were synthesized by the efficient use of a PhSe group. Among them, (+)-4(5)-[(2R, SR)-5-(aminomethyl)tetrahydrofuran-2-yl]imidazole (imifuramine) was indicated as a novel type of histamine H₃-agonist by a brain microdialysis method.

Full text of DOI:10.1016/S0040-4039(99)00202-6

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Product name:(3R,5R)-5-Benzyloxymethyl-3-phenylselanyl-dihydro-furan-2-one

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