Synthesis of imifuramine and its stereoisomers exhibiting histamine H3- agonistic activity

DOI: 10.1016/S0040-4039(99)00202-6

Source and publish data:

Tetrahedron Letters p. 2561 - 2564 (1999)

Update date:2022-08-05

Topics:

Authors:

Harusawa, Shinya

Imazu, Tomonari

Takashima, Seiichiroh

Araki, Lisa

Ohishi, Hirofumi

Kurihara, Takushi

Yamamoto, Yumiko

Atsushi Yamatodani

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(99)00202-6

The four possible stereoisomers of a novel imidazole C-nucleoside derivative were synthesized by the efficient use of a PhSe group. Among them, (+)-4(5)-[(2R, SR)-5-(aminomethyl)tetrahydrofuran-2-yl]imidazole (imifuramine) was indicated as a novel type of histamine H₃-agonist by a brain microdialysis method.

Full text of DOI:10.1016/S0040-4039(99)00202-6

Products guided by the article

Product name:(3R,5R)-5-Benzyloxymethyl-3-phenylselanyl-dihydro-furan-2-one

Cas No:222419-10-5

R&D Labs maybe for 222419-10-5

Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
SINO GREAT ENTERPRISE LTD.

Contact:+86-731-84427351

Address:154 JIANXIANG SOUTH ROAD
HEBEI BRANT PHARMACEUTICAL

Contact:+86-0311-84455288-844

Address:Mayu Industrial Park, Jinzhou, Hebei, China.
Chengda Pharmaceuticals Co., Ltd.

Contact:+86-573-84601188

Address:hengshan Road 5# in Jiashan, zhejiang
MedicalChem(Yancheng)Manuf.Co.,Ltd.

Contact:+86-515-84383366

Address:Touzeng BinHai, YanCheng City, JiangSu Province, China

Relevant to this article

Branched non-covalent complexes between carboxylic acids and two tris(amidines)

Doi:10.1039/a809190k
(1999)
Dichloro<2-<(η⁵-cyclopentadienyl)phenylmethyl>phenolato-O>titanium

Doi:10.1107/S0108270198015479
(1999)
Cp₂TiX Complexes for Sustainable Catalysis in Single-Electron Steps

Doi:10.1002/chem.201705707
(2018)
The efficient stereoselective synthesis of (2S,3R,4S,5S,6S,11E)3-amino- 6-methyl-12-(4-methoxyphenyl)-2,4,5-trihydroxydodec-11-enoic acid (AMMTD), a component of microsclerodermins of marine sponge origin, as its protected form

Doi:10.1016/S0040-4039(99)00411-6
(1999)
Synthetic studies towards western and eastern macropolypeptide subunits of Kistamycin

Doi:10.1016/S0040-4020(99)00171-4
(1999)
Reactions of cis and trans beat, aryl osmium complexes (cat == l,2-O2CeH4). Bis(bcat) complexes of osmium and ruthenium and a structural comparison ofcis and trans isomers of Os(Bcat)I(CO)2(PPh3)2

Doi:10.1021/om0004601
(2000)

Article Doi