Synthesis of Fmoc-protected 4-carboxydifluoromethyl-L-phenylalanine: A phosphotyrosyl mimetic of potential use for signal transduction studies

DOI: 10.1016/S0040-4020(99)00076-9

Source and publish data:

Tetrahedron p. 2865 - 2874 (1999)

Update date:2022-09-26

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Authors:

Yao, Zhu-Jun

Gao, Yang

Voigt, Johannes H.

Ford Jr., Harry

Burke Jr., Terrence R.

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Article abstract of DOI:10.1016/S0040-4020(99)00076-9

4-(Carboxymethyl)phenylalanine (2) and its α,α-difluoro homologue 4- (carboxydifluoromethyl)-phenylalanine (3) have been described as phosphotyrosyl mimetics. Herein we report the synthesis of N-Fmoc 4-(O-tert- butyl carboxymethyl)phenylalanine (4) and N-

Full text of DOI:10.1016/S0040-4020(99)00076-9

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