Bioorganic and Medicinal Chemistry Letters p. 161 - 166 (1999)
Update date:2022-07-29
Topics:
Pieters, Roland J.
Fennema, Marko
Kellogg, Richard M.
Janssen, Dick B.
Bifunctional molecules containing both a biotin and a substrate unit have been designed and synthesized for phage display screening of mutant libraries of haloalkane enzymes. The molecules were assembled using a convergent modular synthetic strategy. One molecule was synthesized to evaluate the concept of covalent capture and a second for screening of phage libraries for enantioselectivity.
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(1999)