Diastereoselective synthesis of 2,4,5-trisubstituted piperidines from enantiopure β-amino esters

Article abstract of DOI:10.1016/S0040-4039(99)00537-7

Reaction of (R)-β-amino esters with methyl acrylate followed by Dieckmann condensation and enol silylation afforded the enol ethers 5, which were hydrogenated with catalysis by Raney-Ni to provide 2,4,5-trisubstituted piperidines with high diastereoselectivity.