Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides.

DOI: 10.1016/S0960-894X(99)00073-6

Source and publish data:

Bioorganic and medicinal chemistry letters p. 749 - 754 (1999)

Update date:2022-08-04

Topics:

Authors:

Parmee Parmee

Naylor Naylor

Perkins Perkins

Colandrea

Candelore

Cascieri

Deng Deng

Feeney Feeney

Forrest Forrest

Hom Hom

MacIntyre

Miller Miller

Stearns Stearns

Strader Strader

Tota Tota

Wyvratt Wyvratt

Fisher Fisher

Weber Weber

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Article abstract of DOI:10.1016/S0960-894X(99)00073-6

Human beta3 adrenergic receptor agonists containing 5-membered ring ureas were shown to be potent partial agonists with excellent selectivity over beta1 and beta2 binding. L-760,087 (4a) and L-764,646 (5a) (beta3 EC50 = 18 and 14 nM, respectively) stimula

Full text of DOI:10.1016/S0960-894X(99)00073-6

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