Synthesis of C2-symmetric bis(cyclic isothioureas) as potent inhibitors of glycosidases

Article abstract of DOI:10.1016/S0040-4039(99)00593-6

Enantiopure C₂-symmetric bis(cyclic isothioureas), considered as potent inhibitors of glycosidases, have been synthesized from D-mannitol. The key step involved a mercuriccatalyzed transformation of a cyclic 1,3- thiazolidine-2-thione into a 2-