Bioorganic and Medicinal Chemistry Letters p. 815 - 819 (2000)
Update date:2022-08-05
Topics:
Clark, Richard F.
Ma, Zhenkun
Wang, Sanyi
Griesgraber, George
Tufano, Michael
Yong, Hong
Li, Leping
Zhang, Xiaolin
Nilius, Angela M.
Chu, Daniel T. W.
Or, Yat Sun
A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem. (C) 2000 Elsevier Science Ltd. All rights reserved.
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