Potent HIV protease inhibitors containing a novel (2-Phenylsulfanyl-1-Hydroxyethyl)amide isostere

Article abstract of DOI:10.1016/S0040-4039(99)00707-8

Based on the concept of bioisosterism, we report the design and synthesis of new protease inhibitors. These new compounds incorporate in their backbone the synthon 2-N-Acyl-2-Phenylsulfanyl-1-Hydroxyethyl (I) which confers on the resulting compounds both