Asymmetric synthesis of L-azetidine-2-carboxylic acid and 3-substituted congeners - Conformationally constrained analogs of phenylalanine, naphthylalanine, and leucine

DOI: 10.1016/S0960-894X(99)00218-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1437 - 1442 (1999)

Update date:2022-08-04

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Authors:

Hanessian, Stephen

Bernstein, Naomy

Yang, Rui-Yang

Maguire, Robert

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Article abstract of DOI:10.1016/S0960-894X(99)00218-8

Enantiopure L-azetidine-2-carboxylic acid, the (3R)-phenyl, (3R)- naphthyl and (3S)-isopropyl analogs were prepared based on a zinc-mediated asymmetric addition of allylic halides to the camphor sultam derivative of glyoxylic acid O-benzyl oxime.

Full text of DOI:10.1016/S0960-894X(99)00218-8

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