Bioorganic and Medicinal Chemistry Letters p. 3069 - 3072 (2004)
Update date:2022-08-04
Topics:
Weidner-Wells, Michele A.
Werblood, Harvey M.
Goldschmidt, Raul
Bush, Karen
Foleno, Barbara D.
Hilliard, Jamese J.
Melton, John
Wira, Ellyn
Macielag, Mark J.
A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.
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