The synthesis and antimicrobial evaluation of a new series of isoxazolinyl oxazolidinones

Article abstract of DOI:10.1016/j.bmcl.2004.04.037

A series of oxazolidinone antibacterial agents containing a 5-substituted isoxazol-3-yl moiety were synthesized via a nitrile oxide [3+2] dipolar cycloaddition reaction. These compounds were screened against a panel of susceptible and resistant Gram-positive organisms. Several analogs from this series were comparable to or more potent than linezolid in vitro.