Solid-phase synthesis of hydroxamic acid based TNF-α convertase inhibitors

Article abstract of DOI:10.1016/S0040-4020(99)00347-6

An acid-sensitive linker for the solid phase synthesis of hydroxamic acids is described. Hydroxamic acid based TNFα inhibitors have been prepared by solid phase synthesis: derivatisation of N²-[4-(N-oxyamino)-2R-isobutyl- 3S-aminosuecinyl]-L-te