Solid-phase synthesis of hydroxamic acid based TNF-α convertase inhibitors

DOI: 10.1016/S0040-4020(99)00347-6

Source and publish data:

Tetrahedron p. 7221 - 7232 (1999)

Update date:2022-08-02

Topics:

Authors:

Barlaam, Bernard

Koza, Patrice

Berriot, Julien

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Article abstract of DOI:10.1016/S0040-4020(99)00347-6

An acid-sensitive linker for the solid phase synthesis of hydroxamic acids is described. Hydroxamic acid based TNFα inhibitors have been prepared by solid phase synthesis: derivatisation of N²-[4-(N-oxyamino)-2R-isobutyl- 3S-aminosuecinyl]-L-te

Full text of DOI:10.1016/S0040-4020(99)00347-6

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