Bioorganic and Medicinal Chemistry Letters p. 237 - 242 (1998)
Update date:2022-08-04
Topics:
Maddry, Joseph A.
Bansal, Namita
Bermudez, Luiz E.
Comber, Robert N.
Orme, Ian M.
Suling, William J.
Wilson, Larry N.
Reynolds, Robert C.
A series of hydrolytically-stable aza analogs of arabinofuranose was prepared and evaluated against Mycobacterium tuberculosis and M. avium. The compounds were designed to mimic the putative arabinose donor involved in biogenesis of the essential cell wall polysaccharide, arabinogalactan. Though most compounds displayed little activity in cell culture, one compound showed significantly activity in infected macrophage models.
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