Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

Article abstract of DOI:10.1016/S0960-894X(99)00262-0

A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or pxylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure.