Sulfoxide-mediated diastereoselective Michael additions. New enantioselective synthesis of C-4 substituted 2-pyroaminoadipic acids

Article abstract of DOI:10.1016/S0040-4039(99)01047-3

Diastereoselective reactions of suitably functionalized homochiral β-iminosulfoxides with Michael acceptors provide a new and efficient route for the asymmetric synthesis of C-4 substituted 2-pyroaminoadipates. Extension of the scope of the sulfoxide-mediated aza-enolate conjugate addition (Hua's reaction) has also been explored.