Studies on the phosphonate isostere of nucleoside 3'- and 2'-phosphates as precursors of the related oligonucleotides

Article abstract of DOI:10.1080/07328319908044681

Synthesis of 2',3'-dideoxy-3'-C-(dihydroxyphosphinylmethyl)-adenosine and -thymidine 5, as well as of 2'-deoxy-2'-C-(dihydroxyphosphinylmethyl)- adenosine and -thymidine 9 was accomplished with the use of the universal carbohydrate precursor 3-deoxy-1,2;5,6-di-O-isopropylidene-3-C- (mesyloxymethyl)-α-D-allofuranose (1).