2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: Synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands

DOI: 10.1016/S0960-894X(99)00302-9

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Bioorganic and Medicinal Chemistry Letters p. 1969 - 1972 (1999)

Update date:2022-08-02

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Authors:

Haubmann, Christian

Huebner, Harald

Gmeiner, Peter

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Article abstract of DOI:10.1016/S0960-894X(99)00302-9

The phenylpiperazinylmethyl substituted pyrrolylmethylenemalononitriles of type 3 and 4 were synthesized and evaluated as strong and selective dopamine D4 receptor ligands.

Full text of DOI:10.1016/S0960-894X(99)00302-9

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