Synthesis of a N-acylsulfamide linked dinucleoside and its incorporation into an oligonucleotide

Article abstract of DOI:10.1016/S0960-894X(99)00358-3

A N-acylsulfamide linked thymidine dinucleoside was synthesized and incorporated into an oligonucleotide (ON). The interest is in a linkage analog that has a higher pKa relative to a phosphodiester and when incorporated into ONs is capable of helix formation with complementary RNA. The hybridization property of the resultant ON with RNA was shown to result in significant destabilization.