Tetrahedron Letters p. 6749 - 6752 (1999)
Update date:2022-08-04
Topics:
Hendrix, James A.
Stefany, David W.
A mild reduction of ortho-fluoro benzamides was discovered using LAH. The reaction proceeds cleanly and in moderate yields. The scope of the reaction is explored and a mechanism is proposed. A two carbon spacer between the amide and a 3°amine is optimal for this chelation controlled reaction.
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(1999)
