Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors

DOI: 10.1016/S0960-894X(99)00433-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2531 - 2536 (1999)

Update date:2022-08-04

Topics:

Authors:

Dumas, Jacques

Brittelli, David

Chen, Jinshan

Dixon, Brian

Holia, Hatoum-Mokdad

Koenig, Gerhard

Sibley, Robert

Witowsky, James

Wong, Stephen

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Article abstract of DOI:10.1016/S0960-894X(99)00433-3

Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active cathepsin D inhibitor was identified by high throughput screening. Subsequent optimization led to

Full text of DOI:10.1016/S0960-894X(99)00433-3

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