Bioorganic and Medicinal Chemistry Letters p. 2531 - 2536 (1999)
Update date:2022-08-04
Topics:
Dumas, Jacques
Brittelli, David
Chen, Jinshan
Dixon, Brian
Holia, Hatoum-Mokdad
Koenig, Gerhard
Sibley, Robert
Witowsky, James
Wong, Stephen
Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active cathepsin D inhibitor was identified by high throughput screening. Subsequent optimization led to
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Doi:10.1021/ol990942c
(1999)Doi:10.1039/a904212a
(1999)Doi:10.1055/s-1988-27741
(1988)Doi:10.1039/a905017e
(1999)Doi:10.1080/10426509908037011
(1999)Doi:10.1016/S0014-827X(99)00075-0
(1999)
