Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors

DOI: 10.1016/S0960-894X(99)00433-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2531 - 2536 (1999)

Update date:2022-08-04

Topics:

Authors:

Dumas, Jacques

Brittelli, David

Chen, Jinshan

Dixon, Brian

Holia, Hatoum-Mokdad

Koenig, Gerhard

Sibley, Robert

Witowsky, James

Wong, Stephen

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00433-3

Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active cathepsin D inhibitor was identified by high throughput screening. Subsequent optimization led to

Full text of DOI:10.1016/S0960-894X(99)00433-3

Products guided by the article

Product name:2-amino-5-chloro-N-[4-(6-ethoxy-benzothiazol-2-ylsulfanyl)-phenyl]-benzamide

Cas No:250124-67-5

R&D Labs maybe for 250124-67-5

Hangzhou Taiyan Trading Co., Ltd(expird)

Contact:+86-13777583958

Address:NO.63, Xingyi Street, Xihu District, Hangzhou, Zhejiang, China
Changzhou Ruiping Chemical Co., Ltd

website:http://www.wishchem.com

Contact:+86-519-82324280

Address:No.288-1 Huacheng Road, Jintan
Zouping Fuhai Technology Development Co., Ltd.

Contact:+0532-86934525 18660293207

Address:jiuhu town industrial park Zouping County,bingzhou Provincejiuhu town industrial park
Allicon Pharmaceuticals,Inc.

Contact:+86-519-86339586，13584329896

Address:Changzhou Scientific and Education Park
Compro Shijiazhuang Fine Chemical Co., Ltd

Contact:0086-311-89689838

Address:Economic and Technological Development Zone of Shijiazhuang,Hebei

Relevant to this article

Highly diastereoselective reaction of 2-azanorbornyl enolates with electrophiles

Doi:10.1021/ol990942c
(1999)
Characterization of 2,6-Trip₂H₃C₆GaCl₂, {2,6-Trip₂H₃C₆InCl(μ-Cl)}₂, and {2,6-Trip₂H₃C₆GaCl(μ-OH)}₂ (Trip = 2,4,6-triisoprop

Doi:10.1039/a904212a
(1999)
Convenient Synthesis of Chiral Pyranones from Carbohydrates

Doi:10.1055/s-1988-27741
(1988)
Diastereoselective Baylis-Hillman reaction of 4-oxoazetidine-2-carbaldehydes: Rapid, stereocontrolled and divergent radical synthesis of highly functionalised β-lactams fused to medium rings

Doi:10.1039/a905017e
(1999)
A convenient synthesis of dithieno[2,3-b] [2,3-h]quinolines and pyrimido [4′,5′:4,5]thieno [2,3-b]thieno[2,3-h]quinolines

Doi:10.1080/10426509908037011
(1999)
Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine

Doi:10.1016/S0014-827X(99)00075-0
(1999)

Article Doi