Tetrahedron Letters p. 6339 - 6342 (1999)
Update date:2022-08-05
Topics:
Jung, Michael E.
MacDougall, James M.
The endogenous natriuretic agent LLU-α, 1, has been synthesized from geraniol 4 in 13 steps and 18% overall yield. The two key steps are a Gassman-Sato process to give the phenol 8 and cyclization of the triol 10 with acid to give the chroman 12 with retention of configuration at the tertiary alcohol center. Final oxidation gave 1.
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Doi:10.1016/j.tetasy.2005.08.004
(2005)Doi:10.1016/S0040-4039(99)00143-4
(1999)Doi:10.1039/b813029a
(2008)Doi:10.1039/a906643h
(1999)Doi:10.1016/S0040-4039(99)01539-7
(1999)Doi:10.1016/S0957-4166(99)00342-0
(1999)
